Tnf^tm1.1Sned
Targeted Allele Detail

Summary

• Symbol: Tnf^tm1.1Sned
• Name: tumor necrosis factor; targeted mutation 1.1, Sergei A Nedospasov
• MGI ID: MGI:3527143
• Synonyms: TNF^flox, Tnf^tm1Sned
• Gene: Tnf Location: Chr17:35418357-35420983 bp, - strand Genetic Position: Chr17, 18.59 cM
• Alliance: Tnf^tm1.1Sned page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95684
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin selection cassette was inserted approximately 1 kb downstream of the gene and a third loxP site was inserted in the 3rd intron. The neomycin resistance cassette was subsequently removed by transient cre expression in ES cells. The remaining loxP sites had no effect on gene expression or phenotype. (J:95684)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnf Mutation: 48 strains or lines available

References

• Original: J:95684 Grivennikov SI, et al., Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects. Immunity. 2005 Jan;22(1):93-104
• All: 29 reference(s)