Smad2^tm3Rob
Targeted Allele Detail

Summary

• Symbol: Smad2^tm3Rob
• Name: SMAD family member 2; targeted mutation 3, Elizabeth J Robertson
• MGI ID: MGI:3527155
• Synonyms: Smad2^deltaexon3
• Gene: Smad2 Location: Chr18:76374651-76444034 bp, + strand Genetic Position: Chr18, 51.42 cM
• Alliance: Smad2^tm3Rob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95374
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed PGK-neo replaced a 488-bp fragment containing the alternatively spliced exon 3. Expression of a cre vector excised the floxed neo, leaving a single loxP site in place of exon 3. Expression of transcript lacking exon 3 was increased compared to wild-type and full length mRNA was undetectable in mutant animals. (J:95374)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Smad2 Mutation: 52 strains or lines available

References

• Original: J:95374 Dunn NR, et al., Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile. Genes Dev. 2005 Jan 1;19(1):152-63
• All: 1 reference(s)