Th^tm5Rpa
Targeted Allele Detail

Summary

• Symbol: Th^tm5Rpa
• Name: tyrosine hydroxylase; targeted mutation 5, Richard D Palmiter
• MGI ID: MGI:3527166
• Synonyms: Th^fs, Th^lox/stop
• Gene: Th Location: Chr7:142446516-142453732 bp, - strand Genetic Position: Chr7, 88.06 cM
• Alliance: Th^tm5Rpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110806
• Parent Cell Line: AK18.1 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed pgk-neo cassette was inserted into intron 1. Presence of this cassette interupts expression of the gene. Cre-mediated recombination restores expression. (J:110806)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Th Mutation: 58 strains or lines available

References

• Original: J:110806 Hnasko TS, et al., Cre recombinase-mediated restoration of nigrostriatal dopamine in dopamine-deficient mice reverses hypophagia and bradykinesia. Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8858-63
• All: 9 reference(s)