Gad1^tm1Rpa
Targeted Allele Detail

Summary

• Symbol: Gad1^tm1Rpa
• Name: glutamate decarboxylase 1; targeted mutation 1, Richard D Palmiter
• MGI ID: MGI:3527168
• Synonyms: Gad1^lox
• Gene: Gad1 Location: Chr2:70392109-70432358 bp, + strand Genetic Position: Chr2, 41.63 cM, cytoband D
• Alliance: Gad1^tm1Rpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126581
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by loxP site and a frt-flanked neo cassette was inserted downstream of exon 2. The neo cassette was removed by Flp-mediated recombination. (J:126581)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gad1 Mutation: 65 strains or lines available

References

• Original: J:126581 Chattopadhyaya B, et al., GAD67-mediated GABA synthesis and signaling regulate inhibitory synaptic innervation in the visual cortex. Neuron. 2007 Jun 21;54(6):889-903
• All: 11 reference(s)