Ndufs4^tm1Rpa
Targeted Allele Detail

Summary

• Symbol: Ndufs4^tm1Rpa
• Name: NADH:ubiquinone oxidoreductase core subunit S4; targeted mutation 1, Richard D Palmiter
• MGI ID: MGI:3527173
• Synonyms: Ndufs4^lox
• Gene: Ndufs4 Location: Chr13:114424331-114524630 bp, - strand Genetic Position: Chr13, 64.12 cM, cytoband D2.2
• Alliance: Ndufs4^tm1Rpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134334
• Parent Cell Line: AK18.1 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 2 and an additional loxP site was inserted upstream of exon 2. Germ line, flp mediated recombination was used to remove the neo cassette. Exon 2 contains the mitochondrial targeting sequence. (J:134334)

Disease models

Expression

In Structures Affected by this Mutation:

16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ndufs4 Mutation: 29 strains or lines available

References

• Original: J:134334 Kruse SE, et al., Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy. Cell Metab. 2008 Apr;7(4):312-20
• All: 24 reference(s)