Agrp^{tm2(HBEGF)Rpa}
Targeted Allele Detail

Summary

• Symbol: Agrp^{tm2(HBEGF)Rpa}
• Name: agouti related neuropeptide; targeted mutation 2, Richard D Palmiter
• MGI ID: MGI:3527177
• Synonyms: Agrp^DTR, Agrp^tm2(DTR)Rpa
• Gene: Agrp Location: Chr8:106293327-106306477 bp, - strand Genetic Position: Chr8, 53.04 cM, cytoband D1-D2
• Alliance: Agrp^{tm2(HBEGF)Rpa} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132360
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Agrp^{tm2(HBEGF)Rpa} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: The human diphtheria toxin receptor followed by an IRES-DsRed2 reporter gene was targeted to the Agrp locus to allow conditional killing of these cells. Germ-line, cre-mediated recombination was used to remove the neo cassette. (J:132360)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Agrp Mutation: 17 strains or lines available

References

• Original: J:132360 Luquet S, et al., NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science. 2005 Oct 28;310(5748):683-5
• All: 17 reference(s)