Akr1c18^tm1Jni
Targeted Allele Detail

Summary

• Symbol: Akr1c18^tm1Jni
• Name: aldo-keto reductase family 1, member C18; targeted mutation 1, James N Ihle
• MGI ID: MGI:3527218
• Synonyms: 20alpha-HSD^-
• Gene: Akr1c18 Location: Chr13:4182614-4200645 bp, - strand Genetic Position: Chr13, 2.31 cM
• Alliance: Akr1c18^tm1Jni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95560
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3, encoding essential components of the enzyme's active site, were replaced with a neo in reverse transcription orientation. Western blot of mutant adrenal, kidney and ovary confirmed the lack of protein. (J:95560)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akr1c18 Mutation: 29 strains or lines available

References

• Original: J:95560 Piekorz RP, et al., Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase. Mol Endocrinol. 2005 Feb;19(2):431-40
• All: 2 reference(s)