Il23a^tm1Dnax
Targeted Allele Detail

Summary

• Symbol: Il23a^tm1Dnax
• Name: interleukin 23, alpha subunit p19; targeted mutation 1, DNAX Research Institute of Cellular and Molecular Biology
• MGI ID: MGI:3527219
• Synonyms: Il-23^-, IL23a^-, Il23a^tm1Cua, Il-23p19^-, Il23p19^tm1Dnax
• Gene: Il23a Location: Chr10:128132009-128133953 bp, - strand Genetic Position: Chr10, 76.51 cM, cytoband D3
• Alliance: Il23a^tm1Dnax page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89968
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo replaced exons 1-4. Quantitative RT-PCR analysis of mutant lymph node tissue demonstrated the complete lack of transcript. (J:89968)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il23a Mutation: 27 strains or lines available

References

• Original: J:89968 Cua DJ, et al., Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature. 2003 Feb 13;421(6924):744-8
• All: 58 reference(s)