Tg(Igh-V186.2-TCL1A)3Cro
Transgene Detail

Summary

• Symbol: Tg(Igh-V186.2-TCL1A)3Cro
• Name: transgene insertion 3, Carlo M Croce
• MGI ID: MGI:3527221
• Synonyms: Emu-TCL1, EmuTCL1, TCL1-Tg, TG line 3
• Transgene: Tg(Igh-V186.2-TCL1A)3Cro Location: unknown
• Alliance: Tg(Igh-V186.2-TCL1A)3Cro page

Transgene origin

• Strain of Origin: C57BL/6 x C3H

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igh-V186.2-TCL1A)3Cro expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TCL1A (8115)

  Tcl1	(MGI:1097166)

• Mutation details: A 350 bp fragment encoding the entire human TCL1A coding region was placed under the transcriptional control of the mouse Igh-V186.2 promoter and the Igh-mu enhancer sequence. 3'UTR and polyA sequences were derived from the human Beta-globin gene. Transgene expression was detected in the spleen and bone marrow, but not the liver. (J:76574)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Igh-V186.2-TCL1A)3Cro

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:76574 Bichi R, et al., Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6955-60
• All: 111 reference(s)