Dok2^tm1Ppp
Targeted Allele Detail

Summary

• Symbol: Dok2^tm1Ppp
• Name: docking protein 2; targeted mutation 1, Pier Paolo Pandolfi
• MGI ID: MGI:3527246
• Gene: Dok2 Location: Chr14:71003476-71015935 bp, + strand Genetic Position: Chr14, 36.71 cM, cytoband D2-D3
• Alliance: Dok2^tm1Ppp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95334
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 2 was disrupted by the insertion of a cassette containing EGFP and neo (in inverse orientation). Western blot analysis of splenocytes did not detect protein gene product. EGFP expression was not reported. (J:95334)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Dok2^tm1Ppp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dok2 Mutation: 16 strains or lines available

References

• Original: J:95334 Niki M, et al., Role of Dok-1 and Dok-2 in leukemia suppression. J Exp Med. 2004 Dec 20;200(12):1689-95
• All: 9 reference(s)