Calca^tm1Rfg
Targeted Allele Detail

Summary

• Symbol: Calca^tm1Rfg
• Name: calcitonin/calcitonin-related polypeptide, alpha; targeted mutation 1, Robert F Gagel
• MGI ID: MGI:3527257
• Synonyms: Calca^-, Ct/Cgrp^-, Ctcgrp null
• Gene: Calca Location: Chr7:114230713-114235592 bp, - strand Genetic Position: Chr7, 59.99 cM
• Alliance: Calca^tm1Rfg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80827
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exons 2-5. RT-PCR analysis of mutant thyroid glands confirmed successful transcript ablation. Immunohistochemistry further demonstrated the lack of protein in mutant thyroids. (J:80827)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Calca Mutation: 23 strains or lines available

References

• Original: J:80827 Hoff AO, et al., Increased bone mass is an unexpected phenotype associated with deletion of the calcitonin gene. J Clin Invest. 2002 Dec;110(12):1849-57
• All: 19 reference(s)