Dok1^tm1Ppp
Targeted Allele Detail

Summary

• Symbol: Dok1^tm1Ppp
• Name: docking protein 1; targeted mutation 1, Pier Paolo Pandolfi
• MGI ID: MGI:3527270
• Synonyms: p62^dok-
• Gene: Dok1 Location: Chr6:83007915-83010448 bp, - strand Genetic Position: Chr6, 35.94 cM
• Alliance: Dok1^tm1Ppp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95640
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette was used to replace exons 1 through 4 and part of exon 5. Western blot analysis of spleen and thymus did not detect protein gene product. (J:95640)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Dok1^tm1Ppp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dok1 Mutation: 19 strains or lines available

References

• Original: J:95640 Di Cristofano A, et al., p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl). J Exp Med. 2001 Aug 6;194(3):275-84
• All: 9 reference(s)