Atp1a1^tm2Ling
Targeted Allele Detail

Summary

• Symbol: Atp1a1^tm2Ling
• Name: ATPase, Na+/K+ transporting, alpha 1 polypeptide; targeted mutation 2, Jerry B Lingrel
• MGI ID: MGI:3527337
• Synonyms: alpha1^S
• Gene: Atp1a1 Location: Chr3:101483535-101512000 bp, - strand Genetic Position: Chr3, 44.3 cM, cytoband F3
• Alliance: Atp1a1^tm2Ling page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95157
• Parent Cell Line: Duffy (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: Two point mutations were introduced into the first extracellular domain of exon 4: R111Q and D122N. Western blot showed that protein expression was normal. (J:95157)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atp1a1 Mutation: 61 strains or lines available

References

• Original: J:95157 Dostanic I, et al., The alpha 1 isoform of Na,K-ATPase regulates cardiac contractility and functionally interacts and co-localizes with the Na/Ca exchanger in heart. J Biol Chem. 2004 Dec 24;279(52):54053-61
• All: 13 reference(s)