Dok1^tm1Yyam
Targeted Allele Detail

Summary

• Symbol: Dok1^tm1Yyam
• Name: docking protein 1; targeted mutation 1, Yuji Yamanashi
• MGI ID: MGI:3527415
• Gene: Dok1 Location: Chr6:83007915-83010448 bp, - strand Genetic Position: Chr6, 35.94 cM
• Alliance: Dok1^tm1Yyam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95641
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette was used to replace the entire coding region, including the initiation and termination codons. Immunoblot analysis of splenocyte did not detect protein gene product. (J:95641)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dok1 Mutation: 19 strains or lines available

References

• Original: J:95641 Yamanashi Y, et al., Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling. Genes Dev. 2000 Jan 1;14(1):11-6
• All: 11 reference(s)