Dok2^tm1Yyam
Targeted Allele Detail

Summary

• Symbol: Dok2^tm1Yyam
• Name: docking protein 2; targeted mutation 1, Yuji Yamanashi
• MGI ID: MGI:3527416
• Gene: Dok2 Location: Chr14:71003476-71015935 bp, + strand Genetic Position: Chr14, 36.71 cM, cytoband D2-D3
• Alliance: Dok2^tm1Yyam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95335
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo-bpA cassette was used to disrupt the entire coding region, including the initiation and termination codons. Immunoblot analysis of bone marrow cells did not detect protein gene product. (J:95335)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dok2 Mutation: 16 strains or lines available

References

• Original: J:95335 Yasuda T, et al., Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia. J Exp Med. 2004 Dec 20;200(12):1681-7
• All: 10 reference(s)