Jak3^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Jak3^tm1Flv
• Name: Janus kinase 3; targeted mutation 1, Richard A Flavell
• MGI ID: MGI:3527456
• Gene: Jak3 Location: Chr8:72129027-72143221 bp, + strand Genetic Position: Chr8, 34.43 cM
• Alliance: Jak3^tm1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95794
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• A 5.5 kb fragment encoding the kinase domain was deleted. (J:95794)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jak3 Mutation: 84 strains or lines available

References

• Original: J:95794 Eynon EE, et al., Disruption of cytokine signaling in lymphoid development: unique contributions of the common cytokine gamma chain and the Jak3 kinase. J Interferon Cytokine Res. 1996 Sep;16(9):677-84
• All: 2 reference(s)