W10q17^M16i
QTL Variant Detail

Summary

• QTL variant: W10q17^M16i
• Name: weight 10 weeks QTL 17; M16i
• MGI ID: MGI:3527709
• QTL: W10q17 Location: Chr13:55720354-112431103 bp Genetic Position: Chr13, Syntenic

Variant origin

• Strain of Specimen: M16i

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased body weight at 10 weeks compared to L6. (J:87794)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

This allele may be consistent with a an additive or dominant mode of inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87794

More than 1000 animals from an (M16i x L6)F2 intercross were typed for 63 polymorphic markers over 19 autosomes to identify QTLs associated with growth traits. Body weight was measured at 21, 42, and 70 days of age. Tail length was measured at 70 days asan indicator of skeletal growth. Parental strain M16i exhibits high weight gain between 21 and 42 days of age while parental strain L6 exhibits low weight gain. LOD=3.3 was used as the cutoff for statistically significant linkage.

Egaq4 maps to an interval on mouse Chromosome 13 between D13Mit27 and D13Mit53. Egaq4 peaks at 35 cM (LOD=3.7) and the QTL interval spans 28.1 cM - 46.8 cM. M16i-derived alleles confer increased early growth with a recessive mode of inheritance. This locus explains 2.3% of the variance.

An interval on mouse Chromosome 13 between D13Mit21 and D13Mit53 contains QTLs W6q16 (LOD=3.6), Tailq3 (LOD=7.1), Tailaq3 (LOD=4.1), and W10q17 (LOD=4.2). W6q16 peaks at 49.5 cM and the QTL interval spans 37.1 cM - 60.6 cM. M16i-derived alleles at W6q16 confer increased body weight at 6 weeks of age with a recessive mode of inheritance. This locus explains 1.9% of the variance. Tailq3 peaks at 54.1 cM and M16i-derived alleles confer increased tail length with an additive or dominant mode of inheritance. This locus explains 3.4% of the variance. Tailaq3 peaks at 54.1 and M16i-derived alleles confer increased tail length adjusted for body weight at 6 weeks of age with an additive or dominant mode of inheritance. This locus explains 2.2% of the variance. W10q17 peaks at 55.4 cM and M16i-derived alleles confer increased body weight at 10 weeks of age with an additive or dominant mode of inheritance. This locus explains 1% of the variance.

References

• Original: J:87794 Rocha JL, et al., A large-sample QTL study in mice: I. Growth. Mamm Genome. 2004 Feb;15(2):83-99
• All: 1 reference(s)