W3q6^M16i
QTL Variant Detail

Summary

• QTL variant: W3q6^M16i
• Name: weight 3 weeks QTL 6; M16i
• MGI ID: MGI:3527717
• QTL: W3q6 Location: Chr15:78601103-102901704 bp Genetic Position: Chr15, Syntenic

Variant origin

• Strain of Specimen: M16i

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased body weight at 3 weeks compared to L6. (J:87794)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

This allele may be consistent with an additive or dominant mode of inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87794

More than 1000 animals from an (M16i x L6)F2 intercross were typed for 63 polymorphic markers over 19 autosomes to identify QTLs associated with growth traits. Body weight was measured at 21, 42, and 70 days of age. Tail length was measured at 70 days asan indicator of skeletal growth. Parental strain M16i exhibits high weight gain between 21 and 42 days of age while parental strain L6 exhibits low weight gain. LOD=3.3 was used as the cutoff for statistically significant linkage.

An interval on mouse Chromosome 15 between D15Mit13 and D15Mit1 contains QTLs Tailaq4, Tailq6, and W3q7. Tailq4 peaks at 21 cM and M16i-derived alleles confer increased tail length adjusted for 6 week body weight with an additive or dominant mode of inheritance. This locus explains 2.6% of the variance. Tailq6 peaks at 27.1 cM and the QTL interval spans 10.8 cM - 40.4 cM. M16i-derived alleles at Tailq6 confer increased tail length with an additive or dominant mode of inheritance. This locus explains 2.1% of the variance. W3q7peaks at 35.3 cM and the QTL interval spans 25.1 cM - 46.3 cM. M16i-derived alleles at W3q7 confer increased body weight at 3 weeks of age with an additive or dominant mode of inheritance. This locus explains 1.9% of the variance.

W3q6 maps to an interval between D15Mit1 and D15Mit15. W3q6 peaks at 49.4 cM (LOD=5.6) and the QTL intervals spans 46.3 cM - 53.1 cM. M16i-derived alleles confer increased body weight at 6 weeks of age with an additive or dominant mode of inheritance. This locus explains 2.1% of the variance.

References

• Original: J:87794 Rocha JL, et al., A large-sample QTL study in mice: I. Growth. Mamm Genome. 2004 Feb;15(2):83-99
• All: 1 reference(s)