Upk2^tm1Tsun
Targeted Allele Detail

Summary

• Symbol: Upk2^tm1Tsun
• Name: uroplakin 2; targeted mutation 1, Tung-Tien Sun
• MGI ID: MGI:3527893
• Gene: Upk2 Location: Chr9:44364012-44366064 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Upk2^tm1Tsun page

Upk2^tm1Tsun/Upk2^tm1Tsun urothelium lacks a typical umbrella cell layer and becomes hyperplastic

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95622
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo replaced exons 1-4 and part of 5. Northern and Western blot confirmed the absence of transcript and protein, respectively, in mutant mice. (J:95622)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Upk2 Mutation: 8 strains or lines available

References

• Original: J:95622 Kong XT, et al., Roles of uroplakins in plaque formation, umbrella cell enlargement, and urinary tract diseases. J Cell Biol. 2004 Dec 20;167(6):1195-204
• All: 1 reference(s)