Cngb1^tm1.1Biel
Targeted Allele Detail

Summary

• Symbol: Cngb1^tm1.1Biel
• Name: cyclic nucleotide gated channel beta 1; targeted mutation 1.1, Martin Biel
• MGI ID: MGI:3527896
• Synonyms: GNGB1^-
• Gene: Cngb1 Location: Chr8:95965673-96033213 bp, - strand Genetic Position: Chr8, 47.12 cM
• Alliance: Cngb1^tm1.1Biel page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95768
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 26 was removed via Cre-mediated excision, leaving a single loxP site. RT-PCR analysis demonstrated no transcript was present in mutant retinas and Western blot using an antibody against the C terminus showed the lack of protein in mutants. (J:95768)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cngb1 Mutation: 61 strains or lines available

References

• Original: J:95768 Huttl S, et al., Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1. J Neurosci. 2005 Jan 5;25(1):130-8
• All: 13 reference(s)