Mapk8ip3^tm1Plhn
Targeted Allele Detail

Summary

• Symbol: Mapk8ip3^tm1Plhn
• Name: mitogen-activated protein kinase 8 interacting protein 3; targeted mutation 1, Pyung-Lim Han
• MGI ID: MGI:3527900
• Synonyms: jsap1^-
• Gene: Mapk8ip3 Location: Chr17:25116480-25155951 bp, - strand Genetic Position: Chr17, 12.53 cM
• Alliance: Mapk8ip3^tm1Plhn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95744
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo in reverse orientation replaced coding sequence, including the leucine-zipper domain. Northern blot confirmed absence of transcript for this part of the gene in mutant brain samples. (J:95744)

Expression

In Mice Carrying this Mutation:	48 assay results
In Structures Affected by this Mutation:	22 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk8ip3 Mutation: 53 strains or lines available

References

• Original: J:95744 Ha HY, et al., The axon guidance defect of the telencephalic commissures of the JSAP1-deficient brain was partially rescued by the transgenic expression of JIP1. Dev Biol. 2005 Jan 1;277(1):184-99
• All: 3 reference(s)