Cpe^tm1Yplo
Targeted Allele Detail

Summary

• Symbol: Cpe^tm1Yplo
• Name: carboxypeptidase E; targeted mutation 1, Y Peng Loh
• MGI ID: MGI:3527901
• Synonyms: CPE KO
• Gene: Cpe Location: Chr8:65045576-65146088 bp, - strand Genetic Position: Chr8, 32.3 cM
• Alliance: Cpe^tm1Yplo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95741
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 4 and 5 were deleted via Cre-mediated excision. Western blot of pituitary from mutants confirmed the lack of protein. (J:95741)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cpe Mutation: 27 strains or lines available

References

• Original: J:95741 Cawley NX, et al., The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits. Endocrinology. 2004 Dec;145(12):5807-19
• All: 8 reference(s)