Mchr1^tm1Dgam
Targeted Allele Detail

Summary

• Symbol: Mchr1^tm1Dgam
• Name: melanin-concentrating hormone receptor 1; targeted mutation 1, David G A Morgan
• MGI ID: MGI:3527904
• Synonyms: MCHR1^-
• Gene: Mchr1 Location: Chr15:81119700-81123165 bp, + strand Genetic Position: Chr15, 38.02 cM
• Alliance: Mchr1^tm1Dgam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95740
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo replaced the coding region of both exons. Real time PCR demonstrated that mutant brains expressed no transcript from the locus. (J:95740)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mchr1 Mutation: 25 strains or lines available

References

• Original: J:95740 Astrand A, et al., Mice lacking melanin-concentrating hormone receptor 1 demonstrate increased heart rate associated with altered autonomic activity. Am J Physiol Regul Integr Comp Physiol. 2004 Oct;287(4):R749-58
• All: 3 reference(s)