Ren1^tm3Gom
Targeted Allele Detail

Summary

• Symbol: Ren1^tm3Gom
• Name: renin 1 structural; targeted mutation 3, R Ariel Gomez
• MGI ID: MGI:3527932
• Synonyms: Ren1^d-DTA
• Gene: Ren1 Location: Chr1:133278412-133288058 bp, + strand Genetic Position: Chr1, 57.91 cM
• Alliance: Ren1^tm3Gom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95786
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A neo and diphtheria toxin A chain (DTA) replaced exons 1-7. RT-PCR of mutants demonstrated the lack of wild-type transcript and the presence of DTA transcript. (J:95786)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ren1 Mutation: 35 strains or lines available

References

• Original: J:95786 Pentz ES, et al., Ablation of renin-expressing juxtaglomerular cells results in a distinct kidney phenotype. Am J Physiol Regul Integr Comp Physiol. 2004 Mar;286(3):R474-83
• All: 2 reference(s)