Tg(CTSG-RARA/ZBTB16)#Ppp
Transgene Detail

Summary

• Symbol: Tg(CTSG-RARA/ZBTB16)#Ppp
• Name: transgene insertion, Pier Paolo Pandolfi
• MGI ID: MGI:3527936
• Synonyms: RARalpha-PLZF, RARA-PLZF, RARA/PLZF
• Transgene: Tg(CTSG-RARA/ZBTB16)#Ppp Location: unknown
• Alliance: Tg(CTSG-RARA/ZBTB16)#Ppp page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CTSG-RARA/ZBTB16)#Ppp expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RARA (5914)

  Rara	(MGI:97856)

  human

  ZBTB16 (7704)

  Zbtb16

  (MGI:103222)

• Mutation details: The human derived RARA/ZBTB16 fusion protein was placed unter the expressional control of the human cathepsin-G promoter (CTSG). 2-36 copies of the transgene were incorporated in the DNA in a head to tail and/or tail to head configuration. Transgene expression was detected in the bone marrow. Five lines were made. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:65878)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1  Disease Model	Tg(CTSG-RARA/ZBTB16)#Ppp/0 Tg(CTSG-ZBTB16/RARA)#Ppp/0	Not Specified
tg2	Tg(CTSG-RARA/ZBTB16)#Ppp/0	Not Specified

Phenotypes:

Affected Systems	cx1	tg2
show or hide all annotated terms
cellular	√	√
decreased apoptosis	√	√
growth/size/body		√
enlarged spleen		√
hematopoietic system	√	√
enlarged spleen		√
abnormal definitive hematopoiesis	√
abnormal myelopoiesis	√	√
myeloid hyperplasia		√
anemia	√
thrombocytopenia	√	√
increased leukocyte cell number	√
abnormal bone marrow cell physiology	√
immune system	√	√
enlarged spleen		√
abnormal myelopoiesis	√	√
myeloid hyperplasia		√
increased leukocyte cell number	√
neoplasm	√	N
neoplasm		N
increased leukemia incidence	√
increased acute promyelocytic leukemia incidence	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	cx1
acute promyelocytic leukemia IDs acute promyelocytic leukemia       DOID:0060318 ICD10CM:C92.4 MESH:D015473 NCI:C3182 OMIM:612376 ORDO:520 UMLS_CUI:C0023487 Close	√

Tumor Data

List all tumor models in MMHCdb carrying Tg(CTSG-RARA/ZBTB16)#Ppp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:65878 He LZ, et al., Two critical hits for promyelocytic leukemia. Mol Cell. 2000 Nov;6(5):1131-41
• All: 3 reference(s)