Tg(CTSG-ZBTB16/RARA)#Ppp
Transgene Detail

Summary

• Symbol: Tg(CTSG-ZBTB16/RARA)#Ppp
• Name: transgene insertion, Pier Paolo Pandolfi
• MGI ID: MGI:3527937
• Synonyms: hCG-PLZF-RARA, PLZF-RARA, PLZF-RARalpha
• Transgene: Tg(CTSG-ZBTB16/RARA)#Ppp Location: unknown
• Alliance: Tg(CTSG-ZBTB16/RARA)#Ppp page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CTSG-ZBTB16/RARA)#Ppp expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RARA (5914)

  Rara	(MGI:97856)

  human

  ZBTB16 (7704)

  Zbtb16

  (MGI:103222)

• Mutation details: The human ZBTB16/RARA fusion gene was placed under the transcriptional control of the human cathepsin-G (CTSG) promoter. 2-14 copies of the transgene were incorporated into the DNA in a head to tail and/or a tail to head fashion. Transgene expression was detected in the bone marrow. Two lines were made, L5814 and L602. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:78201)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(CTSG-ZBTB16/RARA)#Ppp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:78201 He LZ, et al., Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL. Nat Genet. 1998 Feb;18(2):126-35
• All: 5 reference(s)