Aph1a^tm1Pcw
Targeted Allele Detail

Summary

• Symbol: Aph1a^tm1Pcw
• Name: aph1 homolog A, gamma secretase subunit; targeted mutation 1, Philip C Wong
• MGI ID: MGI:3527942
• Synonyms: Aph-1a^-
• Gene: Aph1a Location: Chr3:95801281-95805600 bp, + strand Genetic Position: Chr3, 41.47 cM
• Alliance: Aph1a^tm1Pcw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95769
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo replaced exons 1-5 and part of exon 6. Absence of wild-type transcript was confirmed by RT-PCR analysis. (J:95769)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aph1a Mutation: 19 strains or lines available

References

• Original: J:95769 Ma G, et al., APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development. J Neurosci. 2005 Jan 5;25(1):192-8
• All: 2 reference(s)