About   Help   FAQ
Sema3etm1Ddg
Targeted Allele Detail
Summary
Symbol: Sema3etm1Ddg
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; targeted mutation 1, David D Ginty
MGI ID: MGI:3527995
Synonyms: sema3e-
Gene: Sema3e  Location: Chr5:14075290-14306703 bp, + strand  Genetic Position: Chr5, 5.66 cM
Alliance: Sema3etm1Ddg page
The vascular network is disorganized in Sema3etm1Ddg/Sema3etm1Ddg retinas

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95697
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to insert an EGFP and a floxed neo at the start codon, deleting the signal peptide in exon 1. In situ hybridization confirmed the absence of mRNA in mutant mice. (J:95697)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 55 assay results
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sema3e Mutation:  67 strains or lines available
References
Original:  J:95697 Gu C, et al., Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Science. 2005 Jan 14;307(5707):265-8
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory