Plxnd1^tm1Ddg
Targeted Allele Detail

Summary

• Symbol: Plxnd1^tm1Ddg
• Name: plexin D1; targeted mutation 1, David D Ginty
• MGI ID: MGI:3527997
• Synonyms: plexin-D1^-
• Gene: Plxnd1 Location: Chr6:115931772-115971966 bp, - strand Genetic Position: Chr6, 53.72 cM
• Alliance: Plxnd1^tm1Ddg page

Increase in the number of extraretinal vessels in Plxnd1^tm1.1Tmj/Plxnd1^tm1Ddg Tg(CAG-cre/Esr1*)1Egwa/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95697
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting vector containing a floxed pgk-neo-tpA and an IRES-farnesylated EGFP-pA were inserted into exon 1. GFP expression was not observed in mutant mice. (J:95697)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plxnd1 Mutation: 87 strains or lines available

References

• Original: J:95697 Gu C, et al., Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Science. 2005 Jan 14;307(5707):265-8
• All: 17 reference(s)