Rassf1^tm1Gpp
Targeted Allele Detail

Summary

• Symbol: Rassf1^tm1Gpp
• Name: Ras association (RalGDS/AF-6) domain family member 1; targeted mutation 1, Gerd P Pfeifer
• MGI ID: MGI:3528065
• Synonyms: rassf1a^-
• Gene: Rassf1 Location: Chr9:107428752-107439460 bp, + strand Genetic Position: Chr9, 58.12 cM
• Alliance: Rassf1^tm1Gpp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95683
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo replaced exon 1alpha, ablating the 1a isoform but leaving the 1c isoform unaltered. RT-PCR confirmed the absence of 1a and the presence of 1c transcripts. (J:95683)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Rassf1^tm1Gpp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rassf1 Mutation: 26 strains or lines available

References

• Original: J:95683 Tommasi S, et al., Tumor susceptibility of Rassf1a knockout mice. Cancer Res. 2005 Jan 1;65(1):92-8
• All: 13 reference(s)