Aoc3^tm1Salm
Targeted Allele Detail

Summary

• Symbol: Aoc3^tm1Salm
• Name: amine oxidase, copper containing 3; targeted mutation 1, Marko Salmi
• MGI ID: MGI:3528069
• Synonyms: AOC3^-, SSAO-, VAP-1^-
• Gene: Aoc3 Location: Chr11:101221432-101230256 bp, + strand Genetic Position: Chr11, 64.72 cM, cytoband B2-B5
• Alliance: Aoc3^tm1Salm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95656
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo replaced a portion of exon 1. RT-PCR of mutant small intestine, heart and liver confirmed absence of transcript and immunostaining demonstrated the absence of protein. (J:95656)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aoc3 Mutation: 36 strains or lines available

References

• Original: J:95656 Stolen CM, et al., Absence of the endothelial oxidase AOC3 leads to abnormal leukocyte traffic in vivo. Immunity. 2005 Jan;22(1):105-15
• All: 18 reference(s)