Il10ra^NZW
Spontaneous Allele Detail

Summary

• Symbol: Il10ra^NZW
• Name: interleukin 10 receptor, alpha; NZW variant
• MGI ID: MGI:3528086
• Gene: Il10ra Location: Chr9:45165135-45180447 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Il10ra^NZW page

Mutation origin

• Strain of Origin: NZW

Mutation description

• Allele Type: Spontaneous
• Mutation: Nucleotide substitutions
• Mutation details: The mutation of Il10ra cDNA nucleotides (GenBank accession number NM_008348) includes A-to-G transitions at position 160 and 466, C-to-T transitions at position 346, 475, 727, 1099, 1124, 1368, 1381, and 1750, TG-to-CC transitions at position 492 and 493, T-to-C transitions at position 553 and 1585, a G-to-A transition at position 1146, a G-to-C transition at position 1364, a A-to-T transition at position 1464, and a A-to-C transition at position 1707 in the coding region, and G-to-A transitions at position 1936, 2293, 2890 and 3144, a A-to-C transition at position 2002, a T-to-G transition at position 2100, A-to-G transitions at position 2194, 2319, 2485 and 3167, A-to-T transitions at position 2264 and 2341, C-to-T transitions at position 2665 and 3355,a T-to-C transition at position 2796, and a insertion of G between position 3082 and 3083 in the 3' untranslated region. (J:102087)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il10ra Mutation: 32 strains or lines available

Notes

The mutation was originally found in NZW and MRL/n strain by sequence analyses. Conformation polymorphism analysis also showed that only NZW and MRL shared a different polymorphism compared with 129/sv, AKR, BXSB, C3H, C57BL/6, C57BL/10, DBA, NOD, NZB, SJL, SWR strains, and (NZB x NZW)F1 mice shared both NZB and NZW-alleles.

The NZW Il10ra allele was significantly associated with high serum level of anti-chromatin IgG in (NZB x NZW)F1 x NZB backcross mice. Quantitative trait locus (QTL) analyses also showed tight linkage between the NZW IL-10RA Locus and high serum level of IgG anti-chromatin.

References

• Original: J:102087 Qi ZM, et al., Polymorphism of the mouse gene for the interleukin 10 receptor alpha chain (Il10ra) and its association with the autoimmune phenotype. Immunogenetics. 2005 Oct;57(9):697-702
• All: 1 reference(s)