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Stat2tm1Jdf
Targeted Allele Detail
Summary
Symbol: Stat2tm1Jdf
Name: signal transducer and activator of transcription 2; targeted mutation 1, J David Farrar
MGI ID: MGI:3528233
Synonyms: M/H Stat2
Gene: Stat2  Location: Chr10:128106428-128128718 bp, + strand  Genetic Position: Chr10, 76.5 cM
Alliance: Stat2tm1Jdf page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95855
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutation:    Disruption caused by insertion of vector
 
Mutation detailsA sequence within exon 23 beginning with nucleotide 51 was replaced with the corresponding human cDNA encoding the C terminus of the gene and a stop codon. A loxP flanked neo was inserted into intron 23 and subsequently deleted via transient cre expression, leaving a single loxP site. Immunoprecipitation and Western blotting confirmed successful targeting and the presence of a chimeric mouse-human protein in mutants. (J:95855)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stat2 Mutation:  39 strains or lines available
References
Original:  J:95855 Persky ME, et al., IL-12, but not IFN-alpha, promotes STAT4 activation and Th1 development in murine CD4+ T cells expressing a chimeric murine/human Stat2 gene. J Immunol. 2005 Jan 1;174(1):294-301
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory