Stat2tm1Jdf
Targeted Allele Detail
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Symbol: |
Stat2tm1Jdf |
Name: |
signal transducer and activator of transcription 2; targeted mutation 1, J David Farrar |
MGI ID: |
MGI:3528233 |
Synonyms: |
M/H Stat2 |
Gene: |
Stat2 Location: Chr10:128106428-128128718 bp, + strand Genetic Position: Chr10, 76.5 cM
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Alliance: |
Stat2tm1Jdf page
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Germline Transmission: |
Earliest citation of germline transmission:
J:95855
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Parent Cell Line: |
RW-4 (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Disruption caused by insertion of vector
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Mutation details: A sequence within exon 23 beginning with nucleotide 51 was replaced with the corresponding human cDNA encoding the C terminus of the gene and a stop codon. A loxP flanked neo was inserted into intron 23 and subsequently deleted via transient cre expression, leaving a single loxP site. Immunoprecipitation and Western blotting confirmed successful targeting and the presence of a chimeric mouse-human protein in mutants.
(J:95855)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Stat2 Mutation: |
39 strains or lines available
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Original: |
J:95855 Persky ME, et al., IL-12, but not IFN-alpha, promotes STAT4 activation and Th1 development in murine CD4+ T cells expressing a chimeric murine/human Stat2 gene. J Immunol. 2005 Jan 1;174(1):294-301 |
All: |
2 reference(s) |
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