Tg(SERPINA1-HBVX)1655Jtsb
Transgene Detail

Summary

• Symbol: Tg(SERPINA1-HBVX)1655Jtsb
• Name: transgene insertion 1655, Janet S Butel
• MGI ID: MGI:3528241
• Synonyms: 1655, ATX
• Transgene: Tg(SERPINA1-HBVX)1655Jtsb Location: unknown
• Alliance: Tg(SERPINA1-HBVX)1655Jtsb page

Transgene origin

• Strain of Origin: (ICR x B6C3F1)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The fragment spanning nt -1200 to +46 bp of the human SERPINA1 gene was cloned upstream of the HBV X gene cloned from the adw^sub2^/sub subtype. This construct was cloned into PGEM1, which contains the T7 phage promoter. 10-15 copies of the transgene were incorporated into the DNA. Transgene expression was detected in the liver. (J:90305)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(SERPINA1-HBVX)1655Jtsb

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:90305 Lee TH, et al., Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice. J Virol. 1990 Dec;64(12):5939-47
• All: 3 reference(s)