Stzid3^NSY
QTL Variant Detail

Summary

• QTL variant: Stzid3^NSY
• Name: streptozotocin induced diabetes susceptibility 3; NSY
• MGI ID: MGI:3528284
• QTL: Stzid3 Location: Chr11:63319407-94063918 bp Genetic Position: Chr11, Syntenic

Variant origin

• Strain of Specimen: NSY

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to streptozotocin induced diabetes compared to C3H/He. (J:95507)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Notes

Consomic mice display elevated blood glucose following injection with STZ. 57% of consomic mice are diabetic 8 days after STZ injection and display glucosuria and body weight loss.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:95507

A locus conferring susceptibility to streptozotocin (STZ)-induced diabetes was previously mapped to mouse Chromosome 11 in NOD mice. In this study, chromosome 11 consomic mice were created using a related STZ-sensitive donor strain named NSY (the Nogoya-Shabata-Yasuda mouse). Chromosome 11 derived from NSY was introgressed onto the genetic background of STZ-resistant strain C3H/He for 6-7 generations. Donor strain NSY exhibits significantly increased blood glucose after STZ injection compared to background strain C3H/He. Over 90% of parental NSY animals become diabetic and exhibit weight loss 8 days after STZ injection whereas no C3H/He animals become diabetic or exhibit weight loss 8 days after STZ injection.

Chromosome 11 consomic animals (C3H/He-Chr11^NSY) exhibit significantly increased blood glucose after STZ injection compared to background strain C3H/He but significantly less than that of donor strain NSY. 57% of consomic animals become diabetic 8 days after STZ injection compared to 97% in NOD and 0% in C3H/He parental animals. The susceptibility locus on mouse Chromosome 11 is named Stzid (streptozotocin induced diabetes susceptibility). The QTL interval of Stzid is flanked by D11Mit242 (31 cM) and D11Mit70 (54 cM). Previously mapped diabetes susceptibility loci Idd4 (46 cM) and Nidd1n (31 cM) overlap with Stzid.

1.30.2015 Curator Note: Stzid was originally mapped in J:95957 in 2003 using a (C3H/Or x NOD)F1 x NOD backcross, which differs from the cross used here, we consider the current study a separate mapping experiment and have named this QTL Stzid3.

Nxn, nucleoredoxin, maps to 45.2 cM on mouse Chromosome 11 and is considered a positional and functional candidate gene. Sequence analysis of Nxn revealed 2 nucleotide changes between NODand C3H/He. One substitution is a C to A change at position 456 in the coding region. This change does not result in an amino acid substitution. The other substitution, a C to T change, occurs at position 1549 in the 3'UTR. The Nxn sequence is the same between C3H/He and NSY.

References

• Original: J:95507 Babaya N, et al., Susceptibility to streptozotocin-induced diabetes is mapped to mouse chromosome 11. Biochem Biophys Res Commun. 2005 Mar 4;328(1):158-64
• All: 1 reference(s)