Manln8^SM/J
QTL Variant Detail

Summary

• QTL variant: Manln8^SM/J
• Name: mandible length 8; SM/J
• MGI ID: MGI:3528353
• QTL: Manln8 Location: unknown Genetic Position: Chr7, cM position of peak correlated region/allele: 43.46 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:93171

Two different intercrosses totaling 1045 (LG/J x SM/J)F2 intercross animals were used for linkage analysis to identify QTLs for mandible length. A total of 96 microsatellite markers at an average spacing of 23 cM were used in the genome scan. The QTLs identified for mandible length were evaluated for relationship to other mandible traits. 13 QTLs reaching the chromosome- and genome-wide significance threshold of 0.05 were identified.

Manln1 (mandible length 1) mapped to 48 cM on mouse Chromosome 1 near D1Mit7 (LOD=8.66). The QTL interval of Manln1 spans 36 cM - 52 cM. LG/J-derived alleles confer increased mandible length at Manln1 with a dominant mode of inheritance. This locus explains 4% of the variance.

Manln2 mapped to 52 cM on mouse Chromosome 2 near D2Mit370 (LOD=4.64). The QTL interval of Manln2 spans 42 cM - 60 cM. This locus is linked to many different mandible traits affecting the muscle attachment area.

Manln3 mapped to 34 cM on mouse Chromosome 3 in linkage to D3Mit22 (LOD=2.75). The QTL interval of Manln3 spans 14 cM - 56 cM. LG/J-derived alleles confer increased mandible length at Manln3 with a dominant mode of inheritance. This locus explains 1.3% of the variance. Manln3 also shows linkage to several different mandible traits affectingthe alveolar processes (LOD=7.75 at D3Mit22).

Manln4 mapped to 16 cM on mouse Chromosome 4 near D4Mit163 (LOD=3.46). The QTL interval of Manln4 spans 8 cM - 20 cM. This locus is linked to several different mandible traits affecting muscle attachment region. Manln5 mapped to 36 cM near D4Mit17 (LOD=4.94). The QTL interval of Manln5 spans 24 cM - 52 cM. LG/J-derived alleles at Manln5 confer increased mandible length with a dominant mode of inheritance. This locus explains 2.3% of the variance.

Manln6 mapped to 92 cM on mouse Chromosome 6 near D6Mit58 (LOD=3.13). The QTL interval of Manln6 spans 92 cM - 96 cM. LG/J-derived alleles at Manln6 confer increased mandible length with a recessive mode of inheritance. This locus explains 1.5% of the variance.

Manln7 mapped to 18 cM on mouse Chromosome 7 near D7Mit21 (LOD=3.43). The QTL interval of Manln7 spans 0 cM - 32 cM. Manln7 shows linkage to superior condyloid length. Manln8 mapped to 50 cM near D7Nds1 (LOD=4.14). The QTL interval of Manln8 spans 40 cM - 56 cM. LG/J-derived alleles at Manln8 confer increased mandible length with a dominant mode of inheritance. This locus explains 1.9% of the variance.

Manln9 mapped to 88 cM on mouse Chromosome 10 near D10Mit133 (LOD=4.24). The QTL interval of Manln9 spans62 cM - 88 cM. LG/J-derived alleles at Manln9 confer increased mandible length with a dominant mode of inheritance. This locus explains 2% of the variance.

Manln10 mapped to 0 cM on mouse Chromosome 11 near D11Mit62 (LOD=2.64). The QTL interval of Manln10 spans 0 cM - 56 cM. Manln10 is linked to several mandible traits affecting the muscle attachment region. Manln11 mapped to 50 cM on mouse Chromosome 11 near D11Mit64 (LOD=11.88). The QTL interval of Manln11 spans 30 cM - 72 cM. LG/J-derived alleles atManln11 confer increased mandible length with a dominant mode of inheritance. This locus explains 5.5% of the variance. Manln12 mapped to 98 cM near D11Mit333 (LOD=3.53). This locus is linked to several different mandible traits affecting the muscle attachment region and alveolar processes.

Manln13 mapped to 24 cM on mouse Chromosome 13 near D13Mit115 (LOD=3.42). The QTL interval of Manln13 spans 8 cM - 44 cM. LG/J-derived alleles at Manln13 confer increased mandible length with a dominant mode of inheritance. This locus explains 1.6% of the variance. Manln14 mapped to 74 cM near D13Mit9 (LOD=3.68). The QTL interval of Manln14 spans 54 cM - 92 cM. LG/J-derived alleles at Manln14 confer increased mandible length with a dominant mode of inheritance. This locus explains 1.7% of the variance.

Manln15 mapped to 0 cM on mouse Chromosome 14 near D14Nds1 (LOD=2.52). The QTL interval of Manln15 spans 0 cM - 14 cM. This locus is linked to several different mandible traits affecting the muscle attachment regionand alveolar processes. Manln16 mapped to 16 cM near D14Nds1 (LOD=7.25). The QTL interval of Manln16 spans 4 cM - 28 cM. LG/J-derived alleles at Manln16 confer increased mandible length with an additive mode of inheritance. This locus explains 3.4% of the variance.

Manln17 mapped to 38 cM on mouse Chromosome 15 near D15Mit5 (LOD=7.59). The QTL interval of Manln17 spans 28 cM - 46 cM. LG/J-derived alleles at Manln17 confer increased mandible length with a dominant mode of inheritance. This locus explains 3.5% of the variance.

Manln18 mapped to 8 cM on mouse Chromosome 17 near D17Mit46 (LOD=4.76). The QTL interval of Manln18 spans 0 cM - 18 cM. LG/J-derived alleles confer increased mandible length with a dominant mode of inheritance. This locus explains2.4% of the variance.

Manln19 mapped to 0 cM on mouse Chromosome 19 near D19Mit16 (LOD=2.46). The QTL interval of Manln19 spans 0 cM - 40 cM. SM/J-derived alleles confer increased mandible length with a dominant mode of inheritance. This locus explains 1.1%of the variance.

References

• Original: J:93171 Cheverud JM, et al., Pleiotropic effects on mandibular morphology II: Differential epistasis and genetic variation in morphological integration. J Exp Zoolog Part A Comp Exp Biol. 2004 Sep 21;302B(5):424-35
• All: 1 reference(s)