Atrx^tm1Rjg
Targeted Allele Detail

Summary

• Symbol: Atrx^tm1Rjg
• Name: ATRX, chromatin remodeler; targeted mutation 1, Richard Gibbons
• MGI ID: MGI:3528480
• Synonyms: Atrx^Fl, Atrx^flox, Atrx^loxP, Atrx^tm1Pick
• Gene: Atrx Location: ChrX:104841221-104972978 bp, - strand Genetic Position: ChrX, 47.26 cM
• Alliance: Atrx^tm1Rjg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95953
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo was inserted into intron 17 and a loxP sites into intron 18. Excision of this exon would still allow production of the shorter isoform containing exons 1-11. (J:95953, J:115836)

Disease models

Expression

In Mice Carrying this Mutation:	195 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Atrx^tm1Rjg

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atrx Mutation: 78 strains or lines available

References

• Original: J:95953 Berube NG, et al., The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis. J Clin Invest. 2005 Feb;115(2):258-67
• All: 36 reference(s)