Csmd1^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Csmd1^tm1Lex
• Name: CUB and Sushi multiple domains 1; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3528558
• Gene: Csmd1 Location: Chr8:15942537-17585602 bp, - strand Genetic Position: Chr8, 8.38 cM, cytoband A2
• Alliance: Csmd1^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94077
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding portion of the first exon along with some first intron sequence was deleted and a selection cassette was inserted in its place after the homologous recombination event. This selection cassette contains a Beta-Galactosidase marker (LacZ) and a Neomycin resistance (Neo) fragment to allow selection in ES cells. qPCR confirmed reduced expression of transcripts containing exon 1 and 2 in the brain. Western blot analysis confirmed the absence of full-length protein expression in the cortex. (J:94077, J:194991, J:209700)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Csmd1 Mutation: 247 strains or lines available

References

• Original: J:194991 Distler MG, et al., Assessment of behaviors modeling aspects of schizophrenia in Csmd1 mutant mice. PLoS One. 2012;7(12):e51235
• All: 7 reference(s)