Cyld^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Cyld^tm1Lex
• Name: CYLD lysine 63 deubiquitinase; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3528559
• Synonyms: Cyld^-
• Gene: Cyld Location: Chr8:89423675-89478573 bp, + strand Genetic Position: Chr8, 43.51 cM
• Alliance: Cyld^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114972
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 2 and 3 were replaced with a lacZ reporter and a neomycin resistance gene. (J:114972)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cyld Mutation: 44 strains or lines available

References

• Original: J:114972 Zhang J, et al., Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice. J Clin Invest. 2006 Nov;116(11):3042-9
• All: 6 reference(s)