Stxbp3^tm1Yt
Targeted Allele Detail

Summary

• Symbol: Stxbp3^tm1Yt
• Name: syntaxin binding protein 3; targeted mutation 1, Yoshikazu Tamori
• MGI ID: MGI:3528591
• Synonyms: Munc18c^-
• Gene: Stxbp3 Location: Chr3:108700496-108747818 bp, - strand Genetic Position: Chr3, 47.73 cM, cytoband F3
• Alliance: Stxbp3^tm1Yt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95938
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P/Ola

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A IRES-neo cassette replaced the exon containing the transcription start site. Northern and Western blot analyses confirmed the absence of transcript and protein, respectively, in mutants. (J:95938)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stxbp3 Mutation: 23 strains or lines available

References

• Original: J:95938 Kanda H, et al., Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization. J Clin Invest. 2005 Feb;115(2):291-301
• All: 1 reference(s)