Mlst8^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Mlst8^tm1Lex
• Name: MTOR associated protein, LST8 homolog (S. cerevisiae); targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3528742
• Synonyms: mLST8^-
• Gene: Mlst8 Location: Chr17:24692525-24698052 bp, - strand Genetic Position: Chr17, 12.39 cM
• Alliance: Mlst8^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137592
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 8 were replaced with an IRES-lacz/neo cassette. The absence of protein product was confirmed by western blot. (J:137592)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mlst8 Mutation: 22 strains or lines available

References

• Original: J:137592 Guertin DA, et al., Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell. 2006 Dec;11(6):859-71
• All: 3 reference(s)