Kmt2a^tm2Sjk
Targeted Allele Detail

Summary

• Symbol: Kmt2a^tm2Sjk
• Name: lysine (K)-specific methyltransferase 2A; targeted mutation 2, Stanley J Korsmeyer
• MGI ID: MGI:3528758
• Synonyms: Mll-Cbb^STOP
• Gene: Kmt2a Location: Chr9:44714652-44792594 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Kmt2a^tm2Sjk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95914
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP-flanked stop cassette upstream of exon 8 of the lysine (K)-specific methyltransferase 2A (Kmt2a) gene. A cassette containing 6.5-kb fragment of murine CREB binding protein (Cbp) cDNA, a Simian virus 40 polyadenylation signal (SV40 pA), and a puromycin resistance sequence (puro) was inserted into exon 8. (J:95914)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kmt2a Mutation: 135 strains or lines available

References

• Original: J:95914 Wang J, et al., Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. EMBO J. 2005 Jan 26;24(2):368-81
• All: 2 reference(s)