Kcnk2^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Kcnk2^tm1Lex
• Name: potassium channel, subfamily K, member 2; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3528830
• Gene: Kcnk2 Location: Chr1:188940127-189134470 bp, - strand Genetic Position: Chr1, 94.22 cM
• Alliance: Kcnk2^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210951
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ and neomycin resistance cassette replaced a portion of exons 2 and 3. Western blot analysis confirmed the absence of protein expression of both isoforms in the brain. (J:210951)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcnk2 Mutation: 34 strains or lines available

References

• Original: J:210951 Namiranian K, et al., Cerebrovascular responses in mice deficient in the potassium channel, TREK-1. Am J Physiol Regul Integr Comp Physiol. 2010 Aug;299(2):R461-9
• All: 9 reference(s)