Nr5a2^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Nr5a2^tm1Lex
• Name: nuclear receptor subfamily 5, group A, member 2; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3528835
• Synonyms: LRH-1^-
• Gene: Nr5a2 Location: Chr1:136770309-136888186 bp, - strand Genetic Position: Chr1, 59.98 cM, cytoband E4
• Alliance: Nr5a2^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97625
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: Exon 1, containing the ATG start codon was disrupted by the insertion of a Betageo gene. In situ hybridization confirmed loss of expression in mutant embryos. (J:97625)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nr5a2 Mutation: 96 strains or lines available

References

• Original: J:97625 Gu P, et al., Orphan Nuclear Receptor LRH-1 Is Required To Maintain Oct4 Expression at the Epiblast Stage of Embryonic Development. Mol Cell Biol. 2005 May;25(9):3492-505
• All: 1 reference(s)