Trpm1^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Trpm1^tm1Lex
• Name: transient receptor potential cation channel, subfamily M, member 1; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3528857
• Synonyms: LexKO 428, TRPM1^-
• Gene: Trpm1 Location: Chr7:63803583-63919523 bp, + strand Genetic Position: Chr7, Syntenic
• Alliance: Trpm1^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154776
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 2-4 were replaced by a selection cassette resulting in a non-functional allele. (J:154776)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Trpm1 Mutation: 101 strains or lines available

References

• Original: J:154776 Morgans CW, et al., TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells. Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19174-8
• All: 22 reference(s)