Mcam^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Mcam^tm1Lex
• Name: melanoma cell adhesion molecule; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3528863
• Gene: Mcam Location: Chr9:44045958-44054024 bp, + strand Genetic Position: Chr9, 24.68 cM
• Alliance: Mcam^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193167
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A selection cassette replaced the first three coding exons. Immunofluorescence analysis confirmed the absence of protein expression in alveolar macrophages from homozygous mice. (J:193167)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mcam Mutation: 34 strains or lines available

References

• Original: J:193167 Wu Q, et al., A Novel Function of MUC18: Amplification of Lung Inflammation during Bacterial Infection. Am J Pathol. 2013 Mar;182(3):819-27
• All: 4 reference(s)