Hrh4^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Hrh4^tm1Lex
• Name: histamine receptor H4; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3528886
• Synonyms: H4R^-, Hrh4^tm1Thr
• Gene: Hrh4 Location: Chr18:13140047-13155939 bp, + strand Genetic Position: Chr18, 6.88 cM
• Alliance: Hrh4^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132140
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 that contains the ATG translation initiation site was replaced with a neo cassette. Authors state that this is a null allele. (J:132140)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hrh4 Mutation: 27 strains or lines available

References

• Original: J:132140 Hofstra CL, et al., Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells. J Pharmacol Exp Ther. 2003 Jun;305(3):1212-21
• All: 20 reference(s)