Mchr1^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Mchr1^tm1Lex
• Name: melanin-concentrating hormone receptor 1; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3528891
• Synonyms: Mch1r^-
• Gene: Mchr1 Location: Chr15:81119700-81123165 bp, + strand Genetic Position: Chr15, 38.02 cM
• Alliance: Mchr1^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136869
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Both exons 1 and 2 from the gene coding for entire coding sequece of the gene were replaced with a neo cassette. The absence of expression was confirmed by RT-PCR on RNA from whole brains of homozygous mice. This is a null allele. (J:136869)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mchr1 Mutation: 25 strains or lines available

References

• Original: J:136869 Roy M, et al., Genetic inactivation of melanin-concentrating hormone receptor subtype 1 (MCHR1) in mice exerts anxiolytic-like behavioral effects. Neuropsychopharmacology. 2006 Jan;31(1):112-20
• All: 3 reference(s)