Padi2^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Padi2^tm1Lex
• Name: peptidyl arginine deiminase, type II; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3528933
• Gene: Padi2 Location: Chr4:140633685-140679897 bp, + strand Genetic Position: Chr4, 73.01 cM, cytoband E1
• Alliance: Padi2^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191116
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ/neo cassette replaced exon 1. Western blot analysis confirmed the absence of protein expression in the brain and spinal cord. (J:191116)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Padi2 Mutation: 47 strains or lines available

References

• Original: J:191116 Raijmakers R, et al., Experimental autoimmune encephalomyelitis induction in peptidylarginine deiminase 2 knockout mice. J Comp Neurol. 2006 Sep 10;498(2):217-26
• All: 6 reference(s)