Spr^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Spr^tm1Lex
• Name: sepiapterin reductase; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3528977
• Gene: Spr Location: Chr6:85110662-85114746 bp, - strand Genetic Position: Chr6, 37.15 cM
• Alliance: Spr^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131376
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and 2 were replaced with a lacZ-neo cassette. The absence of protein product was confirmed by western blot analysis on liver and kidney extracts. (J:131376)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Spr Mutation: 8 strains or lines available

References

• Original: J:131376 Takazawa C, et al., A brain-specific decrease of the tyrosine hydroxylase protein in sepiapterin reductase-null mice--as a mouse model for Parkinson's disease. Biochem Biophys Res Commun. 2008 Mar 21;367(4):787-92
• All: 4 reference(s)